Thomas R Kosten Selected Research

Brain-Derived Neurotrophic Factor (BDNF)

1/2016	Interaction of BDNF with cytokines in chronic schizophrenia.
9/2013	Association of BDNF gene polymorphisms with schizophrenia and clinical symptoms in a Chinese population.
5/2013	Low BDNF is associated with cognitive deficits in patients with type 2 diabetes.
10/2012	Brain-derived neurotrophic factor levels and its Val66Met gene polymorphism predict tardive dyskinesia treatment response to Ginkgo biloba.
7/2012	Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia.
7/2012	Cognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls.
1/2012	BDNF Val66Met variant and smoking in a Chinese population.
9/2011	Decreased serum brain-derived neurotrophic factor levels in schizophrenic patients with tardive dyskinesia.
10/2010	Nicotine dependence and serum BDNF levels in male patients with schizophrenia.
8/2010	The study of BDNF Val66Met polymorphism in Chinese schizophrenic patients.

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Thomas R Kosten Research Topics

Disease

67	Schizophrenia (Dementia Praecox) 10/2023 - 01/2002
44	Cocaine-Related Disorders (Cocaine Addiction) 06/2022 - 04/2002
30	Substance-Related Disorders (Drug Abuse) 05/2024 - 01/2002
30	Opioid-Related Disorders (Opiate Addiction) 01/2023 - 04/2002
16	Substance Withdrawal Syndrome (Withdrawal Symptoms) 01/2021 - 01/2002
14	Tardive Dyskinesia 10/2013 - 05/2007
12	Cognitive Dysfunction 10/2023 - 07/2012
9	Alcoholism (Alcohol Abuse) 09/2023 - 09/2002
8	Tobacco Use Disorder (Nicotine Dependence) 11/2017 - 04/2002
7	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 03/2024 - 08/2014
6	Body Weight (Weight, Body) 01/2021 - 06/2007
5	Weight Gain 01/2023 - 06/2007
5	Psychotic Disorders (Schizoaffective Disorder) 01/2019 - 07/2002
4	Type 2 Diabetes Mellitus (MODY) 03/2019 - 04/2013
3	Mental Disorders (Mental Disorder) 03/2024 - 08/2013
3	Paranoid Disorders (Paranoia) 04/2013 - 05/2005
2	Headache (Headaches) 03/2024 - 11/2003
2	Inflammation (Inflammations) 10/2023 - 10/2016
2	Overweight 01/2023 - 01/2021
2	Major Depressive Disorder (Major Depressive Disorders) 01/2020 - 08/2003
2	Obesity 01/2018 - 12/2008
2	Heroin Dependence (Heroin Abuse) 05/2016 - 04/2004
2	Gambling (Pathological Gambling) 11/2015 - 10/2004
2	Diabetes Mellitus 08/2011 - 04/2011
2	Drug Overdose 01/2005 - 10/2002
2	Cardiotoxicity 02/2004 - 10/2002
1	Borderline Personality Disorder (Personality Disorders, Borderline) 03/2024

Drug/Important Bio-Agent (IBA)

36	Cocaine (Cocaine HCl)IBA 01/2021 - 01/2002
24	Antipsychotic Agents (Antipsychotics)IBA 07/2023 - 06/2007
21	VaccinesIBA 05/2024 - 10/2002
19	Opioid Analgesics (Opioids)IBA 05/2024 - 07/2002
18	Methadone (Dolophine)FDA LinkGeneric 11/2022 - 01/2002
18	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2016 - 12/2007
16	Buprenorphine (Subutex)FDA LinkGeneric 09/2023 - 01/2002
15	Dopamine (Intropin)FDA LinkGeneric 01/2019 - 01/2002
14	Disulfiram (Antabuse)FDA Link 01/2021 - 04/2002
11	Opiate AlkaloidsIBA 12/2015 - 01/2002
11	EnzymesIBA 05/2014 - 05/2007
10	CytokinesIBA 10/2023 - 07/2008
10	Naltrexone (ReVia)FDA LinkGeneric 09/2023 - 07/2003
8	Nicotine FDA Link 01/2024 - 04/2002
8	AntioxidantsIBA 10/2022 - 05/2007
8	Free RadicalsIBA 10/2013 - 05/2007
7	Risperidone (Risperdal Consta)FDA LinkGeneric 07/2023 - 12/2007
7	Superoxide DismutaseIBA 05/2014 - 05/2007
6	Methamphetamine (Desoxyn)FDA LinkGeneric 10/2019 - 10/2008
6	Mixed Function Oxygenases (Monooxygenases)IBA 01/2019 - 02/2013
6	Clozapine (Clozaril)FDA LinkGeneric 01/2014 - 06/2007
5	Heroin (Diamorphine)IBA 05/2016 - 01/2002
4	Bupropion (Wellbutrin)FDA LinkGeneric 01/2024 - 07/2002
4	Fentanyl (Sublimaze)FDA LinkGeneric 10/2022 - 01/2018
3	Exenatide (Byetta)FDA Link 01/2023 - 01/2018
3	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2022 - 08/2013
3	Sertraline (Zoloft)FDA LinkGeneric 01/2022 - 12/2015
3	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2020 - 09/2012
3	Interleukin-2 (IL2)IBA 01/2016 - 05/2009
3	Interleukin-18 (Interleukin 18)IBA 01/2016 - 08/2012
3	Norepinephrine (Noradrenaline)FDA LinkGeneric 08/2014 - 02/2013
3	Dopamine beta-HydroxylaseIBA 07/2013 - 11/2003
2	Opioid Receptors (Opioid Receptor)IBA 09/2023 - 01/2023
2	CBLB502IBA 09/2022 - 10/2019
2	Carrier Proteins (Binding Protein)IBA 09/2022 - 04/2013
2	Naloxone Drug Combination Buprenorphine FDA Link 06/2022 - 09/2004
2	Genetic Markers (Genetic Marker)IBA 06/2022 - 02/2011
2	Aldehyde DehydrogenaseIBA 01/2022 - 01/2009
2	Messenger RNA (mRNA)IBA 01/2022 - 04/2013
2	Tropisetron (Navoban)IBA 01/2020 - 09/2012
2	Guanfacine (Tenex)FDA LinkGeneric 11/2019 - 10/2013
2	lofexidineIBA 11/2019 - 01/2019
2	Minocycline (Cyclops)FDA LinkGeneric 10/2019 - 01/2018
2	CannabinoidsIBA 01/2019 - 10/2018
2	Doxazosin (Cardura)FDA LinkGeneric 01/2019 - 01/2012
2	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2019 - 01/2018
2	Interleukin-6 (Interleukin 6)IBA 01/2016 - 12/2008
2	InterleukinsIBA 01/2016 - 12/2008
2	Nerve Growth Factors (Neurotrophins)IBA 01/2016 - 01/2012
2	Interleukin-8 (Interleukin 8)IBA 01/2016 - 12/2008
2	Dopamine Receptors (Dopamine Receptor)IBA 11/2015 - 07/2013
2	Proteins (Proteins, Gene)FDA Link 07/2014 - 02/2013
2	Superoxides (Superoxide)IBA 05/2014 - 01/2012
2	Dopamine Agonists (Dopamine Agonist)IBA 12/2013 - 04/2002
2	ButyrylcholinesteraseIBA 03/2013 - 03/2013
2	cocaine hydrolaseIBA 03/2013 - 03/2013
2	SmokeIBA 01/2012 - 01/2002
2	Monoamine Oxidase (MAO)IBA 09/2009 - 01/2003
2	Hydrocortisone (Cortisol)FDA LinkGeneric 05/2009 - 04/2002
2	AntibodiesIBA 04/2009 - 01/2005
2	Methylphenidate (Ritalin)FDA LinkGeneric 01/2009 - 04/2002
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2008 - 12/2008
2	Progesterone FDA LinkGeneric 10/2007 - 08/2004
2	Tiagabine (Gabitril)FDA Link 11/2005 - 11/2003
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2004 - 08/2003
2	Desipramine (Pertofrane)FDA LinkGeneric 08/2003 - 01/2002

Therapy/Procedure

30	Drug Therapy (Chemotherapy) 05/2024 - 04/2004
15	Therapeutics 05/2024 - 11/2003
8	Immunotherapy 05/2024 - 10/2002
3	Secondary Prevention 11/2019 - 04/2004
2	Injections 09/2023 - 01/2018
2	Tobacco Use Cessation Devices 01/2023 - 01/2021
2	Nicotine Replacement Therapy 01/2021 - 11/2017